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  • Supplement ingredient made from outdoor cultivated medicinal* mushrooms:
    King Agaricus KA21
    *Definitions of medicinal mushrooms differ by country
Healthcare

Supplement ingredient made from outdoor cultivated medicinal* mushrooms:
King Agaricus KA21
*Definitions of medicinal mushrooms differ by country

Toei Shinyaku Co., Ltd.
King Agaricus KA21

King Agaricus KA21

Effects such as immune support and anti-aging (including hair growth, ED, and cognitive function improvement) have been confirmed through human clinical trials.

As a specialized manufacturer of Agaricus blazei / brasiliensis / subrufescens mushrooms, our company has been engaged in the research and development of outdoor cultivated Agaricus (King Agaricus KA21) in Brazil for nearly 30 years. We hold the highest number of international publications among Agaricus manufacturers, with a total of 34 peer-reviewed papers.
Our strength lies in the scientifically backed data that allows us to provide this ingredient with confidence and safety. Thanks to this solid foundation, users can easily experience the effects, resulting in a high repeat purchase rate. This is a unique premium ingredient that helps us stand out from our competitors.
As a supplement ingredient, it offers potential benefits including immune enhancement (with approximately 30 years of sales history), hair growth support (for both men and women), improvement of ED (erectile dysfunction, patent pending), promotion of Akkermansia muciniphila—a gut bacterium gaining global attention (patented), and improvement of stress-induced cognitive function (patented).
The product has received international awards and is certified under GMP, FSSC 22000, and Halal standards.

Agaricus blazei

Agaricus blazei

Agaricus blazei : The Most Widely Used Immune-Boosting Mushroom in Longevity-Leading Japan

Agaricus (Agaricus blazei / brasiliensis / subrufescens) is a medicinal mushroom native to Brazil, South America. Locally, it is known as the “Mushroom of Sun” for its vigorous vitality, thriving even under direct sunlight. It is recognized globally in the field of integrative medicine as one of the Five Major Mushrooms. In Japan, it is the most widely used medicinal mushroom as an immune-support supplement in integrative treatments. Supporting this, data from the integrative medical field shows that over 60% of people taking supplements for immune support chose Agaricus. However, Agaricus poses a challenge: its effectiveness and safety can vary significantly depending on the strain, cultivation method, and place of origin.
Left: greenhouse, Right: King Agaricus KA21

Left: greenhouse, Right: King Agaricus KA21

Top-Quality Agaricus = Outdoor Cultivated Agaricus

Our ingredient uses the KA21 strain—an exceptionally vigorous strain owned exclusively by our company—cultivated outdoor in Brazil under natural sunlight. Compared to greenhouse-grown Agaricus, which is raised in artificially shaded environments, our outdoor Agaricus grows significantly larger and is rich in key components such as β-glucans and vitamin D, with antioxidant activity over five times higher. Furthermore, thanks to Brazil's fertile soil, our Agaricus contains 26 times more calcium, 10 times more copper, and is also abundant in iron and selenium compared to those grown in Japan. We manufacture this product in a GMP-certified facility without adding any additives, using 100% pure mushroom powder. In addition to its immune-boosting properties and its ability to reduce the side effects of anticancer drugs, outdoor cultivated Agaricus has also been shown to offer a wide range of benefits, including promoting hair growth and improving ED.
Japanese and U.S. Patent Certificates

Japanese and U.S. Patent Certificates

An ingredient backed by extensive data, including human clinical trials

Our strength lies in nearly 30 years of research. We have conducted joint studies with some of Japan’s leading institutions, including the University of Tokyo, Keio University, Tokyo University of Pharmacy and Life Sciences, and the National Center for Geriatrics and Gerontology, as well as with Harvard University in the United States. As a result of these collaborations, we have published 34 international scientific papers, including human clinical trials. We also hold four patents in Japan and two in the United States. Our research has confirmed a wide range of benefits: immune enhancement, reduction of chemotherapy side effects, hair growth (for both men and women), improvement of ED (erectile dysfunction), improvement of ovarian function (fertility support), skin beautification, diet & beauty benefits, promotion of the gut bacterium Akkermansia muciniphila (patented), and support for leaky gut syndrome.

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